Postnatal Exposure to Exogenous progesterone Exacerbates the Prenatally-Induced Abnormal Sperms Production and Function in Rats

This study aimed at clarifying the impact of long-term prenatal and postnatal exposure to exogenous progesterone on sperm production function, relative sex organs weights, levels relevant hormones in rats. Sixty male Wistar rats were included classified into three groups (n=20 each). A test I group had mature born dams treated with prenatally. II exposed during as well periods, a control placebo (olive oil). The revealed significant reduction count, motility, viability higher abnormal forms than (P< 0.05). Similarly, significantly lower serum testosterone FSH LH 0.001). Interestingly, showed pronounced abnormalities, an alarming decrease accretion testicular weight compared (p <0.001). Long-term (prenatal early postnatal) treatment synthetic hurts quantity quality, adversely affecting future fertility.